Issue 27, 2007
From the journal:

Chemical Communications

Palladium-catalysed regioselective addition reaction of ethyl phenylphosphinate with terminal acetylenes: ligand- and solvent-dependent regioselectivity†‡

Satish Kumar Nunea  and  Masato Tanaka*a  

* Corresponding authors

a Chemical Resources Laboratory, Tokyo Institute of Technology, 4259- R1-13 Nagatsuta, Midori-ku, Yokohama 226-8503, Japan
E-mail: m.tanaka@res.titech.ac.jp
Fax: +81 45 924 5279
Tel: +81 45 924 5244

Abstract

Palladium–1,2-bis(diphenylphosphino)ethane complex catalyses regioselective Markovnikov addition of ethyl phenylphosphinate to terminal alkynes in toluene, while the use of tri-tert-butylphosphine as the ligand or ethanol as the solvent leads to regioselectivity reversal.

Graphical abstract: Palladium-catalysed regioselective addition reaction of ethyl phenylphosphinate with terminal acetylenes: ligand- and solvent-dependent regioselectivity

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Article information

DOI
https://doi.org/10.1039/B703165C
Article type
Communication
Submitted
02 Mar 2007
Accepted
10 Apr 2007
First published
27 Apr 2007

Chem. Commun., 2007, 2858-2860

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Palladium-catalysed regioselective addition reaction of ethyl phenylphosphinate with terminal acetylenes: ligand- and solvent-dependent regioselectivity

S. Kumar Nune and M. Tanaka, Chem. Commun., 2007, 2858 DOI: 10.1039/B703165C

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