Issue 27, 2007
From the journal:

Chemical Communications

The relationships between oxidase and synthase activities of flavin dependent thymidylate synthase (FDTS)

Anatoly Chernyshev,a   Todd Fleischmann,a   Eric M. Koehn,a   Scott A. Lesleyb  and  Amnon Kohen*a  

* Corresponding authors

a Department of Chemistry, The University of Iowa, Iowa City, IA, USA
E-mail: amnon-kohen@uiowa.edu
Fax: 01-319-335-1270
Tel: 01-319-335-0234

b The Joint Center for Structural Genomics at The Genomics Institute of Novartis Research Foundation, 10675 JohnJay Hopkins Drive, San Diego, California 92121, USA.

Abstract

New findings lead to a revised understanding of the substrates' binding order, the role of the substrate as an activator, and the observed lag phase in the FDTS catalyzed reaction.

Graphical abstract: The relationships between oxidase and synthase activities of flavin dependent thymidylate synthase (FDTS)

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Article information

DOI
https://doi.org/10.1039/B700977A
Article type
Communication
Submitted
22 Jan 2007
Accepted
10 Apr 2007
First published
25 Apr 2007

Chem. Commun., 2007, 2861-2863

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The relationships between oxidase and synthase activities of flavin dependent thymidylate synthase (FDTS)

A. Chernyshev, T. Fleischmann, E. M. Koehn, S. A. Lesley and A. Kohen, Chem. Commun., 2007, 2861 DOI: 10.1039/B700977A

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