Issue 24, 2007
From the journal:

Chemical Communications

Novel octavalent cross-linker displays efficient trapping of protein–protein interactions†

Simon R. Foster,a   Alice Pearce,b   Alexander J. Blake,a   Melanie J. Welhamb  and  James Dowden*a  

* Corresponding authors

a School of Chemistry, University of Nottingham, University Park, Nottingham, UK
E-mail: james.dowden@nottingham.ac.uk
Fax: 0115 95135654
Tel: 0115 9513566

b Department of Pharmacy and Pharmacology, University of Bath, Calverton Down, Bath, UK

Abstract

A novel octavalent, resorcin[4]arene derived, cross-linker designed to overcome some of the limitations of commercially available reagents is significantly more efficient for covalent stabilisation of protein–protein interactions.

Graphical abstract: Novel octavalent cross-linker displays efficient trapping of protein–protein interactions

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Article information

DOI
https://doi.org/10.1039/B701542A
Article type
Communication
Submitted
01 Feb 2007
Accepted
05 Mar 2007
First published
20 Mar 2007
This article is Open Access

Chem. Commun., 2007, 2512-2514

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Novel octavalent cross-linker displays efficient trapping of protein–protein interactions

S. R. Foster, A. Pearce, A. J. Blake, M. J. Welham and J. Dowden, Chem. Commun., 2007, 2512 DOI: 10.1039/B701542A

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