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Issue 20, 2005
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Recognition of homo-polynucleotides containing adenine by a phenanthridinium bis-uracil conjugate in aqueous media

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Abstract

Among novel bis-nucleobase–phenanthridinium conjugates bis-uracil analogue 2 stabilized significantly more effective poly-dA–poly-dT and poly-AH+–poly-AH+ than adenine analogue 3 and reference compound 1. For the alternating poly-dAdT–poly-dAdT however, the binding preference is lost, pointing to the importance of specific interactions of uracils of 2 with homopolynucleotides containing consecutive adenines.

Graphical abstract: Recognition of homo-polynucleotides containing adenine by a phenanthridinium bis-uracil conjugate in aqueous media

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Publication details

The article was received on 13 Jan 2005, accepted on 09 Mar 2005 and first published on 18 Mar 2005


Article type: Communication
DOI: 10.1039/B500617A
Citation: Chem. Commun., 2005,0, 2561-2563
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    Recognition of homo-polynucleotides containing adenine by a phenanthridinium bis-uracil conjugate in aqueous media

    L. Tumir, I. Piantanida, I. Juranović, Z. Meić, S. Tomić and M. Žinić, Chem. Commun., 2005, 0, 2561
    DOI: 10.1039/B500617A

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