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Issue 20, 2002
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One-pot synthesis of hydrogen phosphonate derivatives of d4T and AZT

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Abstract

A simple and one-pot route for the synthesis of d4T or AZT hydrogen phosphonate derivatives via reaction of d4T or AZT with phosphorus trichloride, then alcoholysis and dealkylation in the presence of the corresponding alcohol is described.

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Article information


Submitted
06 Aug 2002
Accepted
29 Aug 2002
First published
20 Sep 2002

Chem. Commun., 2002, 2414-2415
Article type
Communication

One-pot synthesis of hydrogen phosphonate derivatives of d4T and AZT

X. Bin Sun, J. Xun Kang and Y. Fen Zhao, Chem. Commun., 2002, 2414
DOI: 10.1039/B207657H

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