A novel one step photocatalytic synthesis of dihydropyrazine from ethylenediamine and propylene glycolIICT Communication No 4561.

Abstract

Dihydropyrazine (DHP), the intermediate for pyrazine, is synthesized from ethylenediamine and propylene glycol; it is assumed that the reaction proceeds by photooxidation of propylene glycol and cyclization with ethylenediamine to give dihydromethylpyrazine, which by subsequent oxidative demethylation via the corresponding acid, forms dihydropyrazine; molecular oxygen, light and TiO₂/zeolite promote the reaction.