Issue 9, 2000
From the journal:

Chemical Communications

CFTA, a new efficient agent for determination of absolute configurations of chiral secondary alcohols

Tamiko Takahashi,a   Aki Fukuishima,a   Yuki Tanaka,a   Yoshio Takeuchi,*a   Kuninobu Kabuto*b  and  Chizuko Kabutob  

* Corresponding authors

a Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama, Japan

b Graduate School of Chemistry, Tohoku University, Aoba-ku Aramaki, Sendai, Japan.
E-mail: takeuchi@ms.toyama-mpu.ac.jp

Abstract

The CFTA method using α-cyano-α-fluoro-p-tolylacetic acid (CFTA) can be reliable in assigning absolute configurations of chiral secondary alcohols based on both 1H and 19F NMR spectroscopy, and the most stable and most predominant conformer of the CFTA esters that can explain the 1H and 19F NMR data were supported by X-ray analysis and ab initio calculations.

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Article information

DOI
https://doi.org/10.1039/B001962N
Article type
Communication
Submitted
10 Mar 2000
Accepted
29 Mar 2000
First published
18 Apr 2000

Chem. Commun., 2000, 787-788

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CFTA, a new efficient agent for determination of absolute configurations of chiral secondary alcohols

T. Takahashi, A. Fukuishima, Y. Tanaka, Y. Takeuchi, K. Kabuto and C. Kabuto, Chem. Commun., 2000, 787 DOI: 10.1039/B001962N

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