Bisphosphonate prodrugs: unusual dimerisation of clodronic acid trimethyl ester to a cyclic bis(bisphosphonate)

Marko J. Ahlmark; Markku Ahlgrén; Riku Niemi; Hannu Taipale; Tomi Järvinen; Jouko J. Vepsäläinen

doi:10.1039/B000558O

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Bisphosphonate

Marko J. Ahlmark,*^a Markku Ahlgrén,^b Riku Niemi,^c Hannu Taipale,^c Tomi Järvinen^c and Jouko J. Vepsäläinen^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, University of Kuopio, PO Box 1627, Kuopio, Finland.
E-mail: Marko.Ahlmark@uku.fi

^b Department of Chemistry, University of Joensuu, PO Box 111, Joensuu, Finland

^c Department Pharmaceutical Chemistry, University of Kuopio, PO Box 1627, Kuopio, Finland

Abstract

Cl₂C[P(O)(OMe)₂P(O)(OMe)(O⁻Z⁺)] selectively reacts with acetyl chloride to provide a new enzymatically stable heterocyclic bis(bisphosphonate); the structure is confirmed by X-ray crystallography.

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Supplementary files

Crystal data TXT (30K)

Article information

DOI: https://doi.org/10.1039/B000558O
Article type: Communication
Submitted: 19 Jan 2000
Accepted: 15 Mar 2000
First published: 10 Apr 2000

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Chem. Commun., 2000, 711-712

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