SCHEDULED MAINTENANCE
The synthesis of a spirocyclic analog of huperzine A that bears a cyclopropane ring at its 10-position has been carried out in an enantioselective manner using a diastereoselective Michael–aldol reaction; in assays of AChE inhibition, this compound was found to be nearly as active as huperzine A itself, with comparable on and off rates from the enzyme.
A. P. Kozikowski, K. R. C. Prakash, A. Saxena and B. P. Doctor, Chem. Commun., 1998, 1287 DOI: 10.1039/A801748D
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