Two-step phosphorus-mediated substitution of hydroxy groups in selected primary alcohols for fluorinated alkyl or aryl substituents: the molecular structure of 1,1-bis(fluorosulfonyl)-1-fluoro-2-phenylethane
Abstract
In an Arbuzov type reaction, amido phosphites (Et2N)2- PORand a broad range of halofluoro organic halides (X = Cl, Br) formed the corresponding alkylated derivatives R1–R2 [R1 = Bn, R2 = C(SO2F)3, CCl2F, CCl2CF3, CBr2F, C(CF3)3, C6F5; R1 = Et, CH2CF3, Me, R2 = CCl2CF3], whereas with FC(SO2F)3 and loss of SO2, BnCF(SO2F)2 was obtained, as shown by X-ray crystallography.