The Nin-2,4-dimethylpent-3-yloxycarbonyl (Doc) group is presented as a new protecting group for tryptophan that is stable to nucleophiles and trifluoroacetic acid, suppresses alkylation side reactions and is cleaved by strong acid among with other protecting groups used in Boc solid phase peptide synthesis.
A. Karlström and A. Undén, Chem. Commun., 1996, 1471 DOI: 10.1039/CC9960001471
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