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Issue 12, 1996
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Glycosidase-catalysed synthesis of oligosaccharides: trisaccharides with the α-D-gal-(1 → 3)-D-gal terminus responsible for the hyperacute rejection response in cross-species transplant rejection from pigs to man

Abstract

α-Galactosidases from Coffea arabica, Aspergillus niger and A. oryzae catalyse the transfer of α-galactosyl residues on to lactose thioglycosides to give 1 → 3 and 1 → 6 linked trisaccharides, including an unusual branched trisaccharide 11 and the isoglobotriose glycoside 4, which, as ‘linear B type 6’, has been recognised as of the type responsible for the hyperacute rejection response in pig-to-man xenotransplantation.

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Article type: Paper
DOI: 10.1039/CC9960001473
Citation: Chem. Commun., 1996,0, 1473-1474

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    Glycosidase-catalysed synthesis of oligosaccharides: trisaccharides with the α-D-gal-(1 → 3)-D-gal terminus responsible for the hyperacute rejection response in cross-species transplant rejection from pigs to man

    G. Vic, M. Scigelova, J. J. Hastings, O. W. Howarth and D. H. G. Crout, Chem. Commun., 1996, 0, 1473
    DOI: 10.1039/CC9960001473

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