Stereochemistry in dehydrogenation of 3α, 7α, 12α-trihydroxy-5β-cholestan-26-oyl CoA during cholic acid biosynthesis
Abstract
The dehydrogenation reaction, catalysed by 3α, 7α, 12α-trihydroxy-5β-cholestan-26-oyl CoA oxidase, is elucidated to proceed via syn-elimination of [24-pro-R]-hydrogen and 25-hydrogen.