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Issue 19, 1993
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Atropisomer-selective 1,1-binapthyl synthesis via chirality transfer from sulfur

Abstract

4,5-Dihydro-2-(1-alkyl- or 1-aryl-sulfinylnaphthalen-2-yl)-4,4-dimethyloxazoles 36 undergo substitution reactions on treatment with Grignard reagents; the optically active sulfoxide 14 on treatment with 1-naphthylmagnesium bromide furnished the 1,1-binaphthyl 15 in 60% enantiomeric excess (e.e.).

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Article information


J. Chem. Soc., Chem. Commun., 1993, 1489-1491
Article type
Paper

Atropisomer-selective 1,1-binapthyl synthesis via chirality transfer from sulfur

R. W. Baker, G. R. Pocock and M. V. Sargent, J. Chem. Soc., Chem. Commun., 1993, 1489
DOI: 10.1039/C39930001489

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