(R)-(–)-2-Acetyl-5,8-dimethoxy-1,2,3,4-tetrahydro-2-naphthol 6, a key intermediate for the synthesis of anticancer anthracyclines, has been synthesized enantioselectively in 39% overall yield (8 steps) starting from highly diastereoselective reaction of 1-trimethylsilylbuta-2,3-diene with the chiral acetal 7.
S. Hatakeyama, K. Sugawara and S. Takano, J. Chem. Soc., Chem. Commun., 1991, 1533 DOI: 10.1039/C39910001533
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