Cycloaddition of 2,3,4,5-tetrahydropyridine N-oxide to vinyl ethers. Enantioselective synthesis of 2-(N-benzylpiperidin-2-yl)ethanol
Abstract
The title compound has been obtained in high optical purity by cycloaddition of 2,3,4,5-tetrahydropyridine N-oxide and (R)-2,2-dimethyl-1-phenylpropyl vinyl ether followed by N-benzylation and reduction of the salt with lithium aluminium hydride.