The late stages of the biosynthesis of the diterpenoid aphidicolin in Cephalosporium aphidicola
Abstract
Labelling studies (14C and 18O) have shown that the major biosynthetic pathway leading to the diterpenoid aphidicolin involves the aphidicolan-16β-ols whilst the results of 2H-labelling studies are consistent with a minor pathway involving epoxidation of an aphidicol-16-ene and hydrolysis of the epoxide.