Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 22nd May 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 2, 2016
Previous Article Next Article

High durability and low toxicity antimicrobial coatings fabricated by quaternary ammonium silane copolymers

Author affiliations

Abstract

Adhesion and subsequent growth of microorganisms on material surfaces are a major concern in many biomedical applications. Currently, various polymers are immobilized on material surfaces to prevent microbial colonization. However, there are several challenges with regard to the coating materials, including their inability to kill microorganisms, complexity of surface grafting, limited durability and toxicity towards humans. To address these challenges, we synthesize a novel quaternary ammonium silane (QAS) antimicrobial copolymer to confer the antimicrobial effect via a simple thermal-curing coating process. The QAS copolymers were less toxic to 3 human cell lines than a commercial antimicrobial QAS monomeric agent, namely, dimethyloctadecyl[3-(trimethoxysilyl) propyl]ammonium chloride (DTPAC). Moreover, the QAS coatings demonstrated superior antimicrobial efficacy and durability than those of the DTPAC coatings. In conclusion, the novel QAS copolymers are useful to prevent substrates from microbial infections, yet with low toxicity to humans and long durability. In addition, the synthetic process is potentially scalable for industrial applications.

Graphical abstract: High durability and low toxicity antimicrobial coatings fabricated by quaternary ammonium silane copolymers

Back to tab navigation

Supplementary files

Publication details

The article was received on 29 Aug 2015, accepted on 25 Oct 2015 and first published on 04 Nov 2015


Article type: Paper
DOI: 10.1039/C5BM00353A
Author version
available:
Download author version (PDF)
Biomater. Sci., 2016,4, 299-309

  •   Request permissions

    High durability and low toxicity antimicrobial coatings fabricated by quaternary ammonium silane copolymers

    H. Li, H. Bao, K. X. Bok, C. Lee, B. Li, M. T. Zin and L. Kang, Biomater. Sci., 2016, 4, 299
    DOI: 10.1039/C5BM00353A

Search articles by author

Spotlight

Advertisements