A new indoloquinoline-based fluorescence probe for imaging of hydrazine in vitro and in vivo

Abstract

The detection of hydrazine is critically important due to its potential to cause severe damage to ecosystems. Herein, a novel indoloquinoline-based “turn-off” fluorescent probe was specifically devised and fabricated for the detection of hydrazine. The probe demonstrates excellent qualities including rapid response, high sensitivity, excellent selectivity, and low cytotoxicity in vitro. Furthermore, this probe enables rapid imaging of hydrazine in living animals. These superior properties establish this probe as a promising tool for monitoring hydrazine levels in vitro and in vivo.