New oleanane-type saponins from the leaves of Derris trifoliata

Abstract

Phytochemical investigation of the polar fraction of the leaves of Derris trifoliata led to the isolation of five new oleanane-type saponins, named derristrifosides A–E (1–5). Their chemical structures were elucidated through comprehensive analyses of HR-ESI-MS and one-dimensional and two-dimensional NMR spectra. These new saponins possess a cantoniensistriol-type sapogenin framework, which is rarely found in vascular plants. Compounds 1–5 exhibited weak inhibitory activity against nitric oxide (NO) production in LPS-stimulated RAW 264.7 cells and weak antiproliferative activity against SK-LU-1 and Hep-G2 human cancer cell lines.