Issue 7, 2026
From the journal:

Organic & Biomolecular Chemistry

Directing chiral induction in hollow helical organic nanotubes

Indradip Mandal, ORCID logo a   Justin Vouillamoz ORCID logo a  and  Andreas F. M. Kilbinger ORCID logo *a  

* Corresponding authors

a Department of Chemistry, University of Fribourg, Chemin du Musée 9, 1700 Fribourg, Switzerland
E-mail: andreas.kilbinger@unifr.ch

Abstract

Helical aromatic oligoamides were synthesized via a polymerization strategy from amino acid-derived monomers to probe side-chain steric effects on helical chirality. Circular dichroism revealed tunable, reversible helicity dictated by substituent bulk. This work establishes tubular oligoamides as structurally precise yet responsive foldamers, enabling controlled chiroptical activity through targeted side-chain engineering.

Graphical abstract: Directing chiral induction in hollow helical organic nanotubes

  • This article is part of the themed collection: Foldamers
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Article information

DOI
https://doi.org/10.1039/D5OB01868D
Article type
Paper
Submitted
27 Nov 2025
Accepted
19 Jan 2026
First published
26 Jan 2026
This article is Open Access
Creative Commons BY-NC license

Org. Biomol. Chem., 2026,24, 1503-1509

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Directing chiral induction in hollow helical organic nanotubes

I. Mandal, J. Vouillamoz and A. F. M. Kilbinger, Org. Biomol. Chem., 2026, 24, 1503 DOI: 10.1039/D5OB01868D

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