Controllable site-selective C–C bond cleavage for the divergent synthesis of imidazo[1,5-a]pyridine derivatives

Abstract

Ethyl 3-oxo-3-phenylpropanoate reacts with phenyl(pyridin-2-yl)methanamine to afford a selective product via the site-selective C–C bond cleavage of ethyl 3-oxo-3-phenylpropanoate by adjusting reaction parameters, and a series of imidazo[1,5-a]pyridines can be effectively prepared using this method. This study enables controllable site-selectivity in both C–C bond cleavage and C–C bond formation, which may offer new insights for chemists in the C–C bond cleavage research field.