Issue 50, 2025, Issue in Progress
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RSC Advances

A green approach to 2-arylquinolines via palladium-catalysed C–H activation

Nuno Viduedo, ORCID logo a   Leonardo Pirvu,a   Ângelo Alves,a   Fábio Santos ORCID logo b  and  M. Manuel B. Marques ORCID logo *a  

* Corresponding authors

a LAQV@REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal

b Centro Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal

Abstract

A mild, palladium-catalyzed C–H activation enables direct, sustainable synthesis of 2-arylquinolines from simple allyl amines, with up to 64% yield; green chemistry metrics highlight its superior atom economy and reduced environmental impact compared to conventional methods.

Graphical abstract: A green approach to 2-arylquinolines via palladium-catalysed C–H activation

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Article information

DOI
https://doi.org/10.1039/D5RA05924K
Article type
Paper
Submitted
03 Sep 2025
Accepted
20 Oct 2025
First published
04 Nov 2025
This article is Open Access
Creative Commons BY license

RSC Adv., 2025,15, 42588-42593

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A green approach to 2-arylquinolines via palladium-catalysed C–H activation

N. Viduedo, L. Pirvu, Â. Alves, F. Santos and M. M. B. Marques, RSC Adv., 2025, 15, 42588 DOI: 10.1039/D5RA05924K

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