A multicomponent approach for the stereoselective synthesis of atropisomeric N–N peptide analogues

Abstract

Peptide analogues featuring both central and N–N axial chirality were efficiently synthesised using a 4-component Ugi reaction. This method demonstrates a broad substrate scope, affording the target compounds with excellent stereoselectivity (up to >95 : 5 d.r.). Thermal atropisomerization studies revealed the identity of the substituents significantly influences the configurational stability and thermodynamic preferences of the atropisomeric products.