Synergistic cascade nanozyme of Zr-TPY-Fe/cys/Au for self-augmented chemodynamic therapy in TNBC cells

Wenhui Yang; Xiuli Zhang; Xiaoli Chen; Gen Li; Feifei Yuan; Nan Yu; Liyong Chen; Xuefu Hu

doi:10.1039/D5CC04635A

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Synergistic cascade nanozyme of Zr-TPY-Fe/cys/Au for self-augmented chemodynamic therapy in TNBC cells

Wenhui Yang,†^a Xiuli Zhang,†^a Xiaoli Chen,^a Gen Li,^a Feifei Yuan,^a Nan Yu,*^c Liyong Chen

*^ab and Xuefu Hu

*^a

Author affiliations

* Corresponding authors

^a Department of Pharmaceutical Engineering, Bengbu Medical University, Bengbu, China
E-mail: lychen@bbmu.edu.cn

^b Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, Bengbu, China

^c Anhui Laboratory of Molecule-Based Materials, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, China
E-mail: yn2009@ahnu.edu.cn

Abstract

Multifunctional Zr-TPY-Fe/cy/Au nanosheets are developed for self-boosted chemodynamic therapy (CDT) by combining glucose oxidase (GOx)- and peroxidase (POD)-like activities. Au NPs generate H₂O₂ from glucose, which feeds terpyridine–Fe sites to produce ˙OH, achieving ROS-mediated cytotoxicity in TNBC cells.

Download options Please wait...

Supplementary files

Supplementary information PDF (3311K)

Article information

DOI: https://doi.org/10.1039/D5CC04635A
Article type: Communication
Submitted: 13 Aug 2025
Accepted: 04 Nov 2025
First published: 05 Nov 2025

Download Citation

Chem. Commun., 2025,61, 19116-19119

Permissions

Request permissions

Synergistic cascade nanozyme of Zr-TPY-Fe/cys/Au for self-augmented chemodynamic therapy in TNBC cells

W. Yang, X. Zhang, X. Chen, G. Li, F. Yuan, N. Yu, L. Chen and X. Hu, Chem. Commun., 2025, 61, 19116 DOI: 10.1039/D5CC04635A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications

Synergistic cascade nanozyme of Zr-TPY-Fe/cys/Au for self-augmented chemodynamic therapy in TNBC cells

Abstract

Supplementary files

Article information

Download Citation

Permissions

Synergistic cascade nanozyme of Zr-TPY-Fe/cys/Au for self-augmented chemodynamic therapy in TNBC cells

Social activity

Search articles by author

Spotlight

Advertisements