The synthesis of a fully oxygenated aconitine D ring precursor from (D)-(+)-glucose is described. The route features a highly diastereoselective alkynyl Grignard ketone addition and a base-mediated enelactone to 1,3-diketone rearrangement.
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I. A. Pocock, J. Doulcet, C. R. Rice, J. B. Sweeney and D. M. Gill, Org. Biomol. Chem., 2024, 22, 4347 DOI: 10.1039/D4OB00561A
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