Issue 21, 2024

Visible-light-induced three-component reactions of α-diazoesters, quinazolinones and cyclic ethers toward quinazoline-based hybrids

Abstract

An effective approach for the construction of 4-short-chain ether attached carbonyl group-substituted quinazolines was developed. Visible-light-induced three-component reactions of α-diazoesters, quinazolinones, and cyclic ethers, with a broad substrate scope and excellent functional group tolerance, under extremely mild conditions without the need for any additional additives and catalysts, selectively led to quinazoline-based hybrids in good to excellent yields. The synthesized hybrids, which are a conglomeration of a quinazoline, a short-chain ether, and a carbonyl group in one molecular skeleton, have potential for application in the development of new drugs or drug candidates.

Graphical abstract: Visible-light-induced three-component reactions of α-diazoesters, quinazolinones and cyclic ethers toward quinazoline-based hybrids

Supplementary files

Article information

Article type
Paper
Submitted
24 Feb 2024
Accepted
29 Apr 2024
First published
30 Apr 2024

Org. Biomol. Chem., 2024,22, 4332-4346

Visible-light-induced three-component reactions of α-diazoesters, quinazolinones and cyclic ethers toward quinazoline-based hybrids

Y. Liu, Q. Yang, W. Wang, Y. Fu, Q. Ding and Y. Peng, Org. Biomol. Chem., 2024, 22, 4332 DOI: 10.1039/D4OB00295D

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