Issue 7, 2024

Synthesis of 20-nm-sized CoAl-LDH nanoparticles modified with folic acid for enhanced cancer cell targeting

Abstract

Nanomaterials with a highly exposed surface are a topic of growing interest for their application in chemodynamic therapy (CDT). In this study, we have demonstrated a facile synthesis of 20-nm-sized CoAl layered double hydroxide (LDH) nanoparticles modified with folic acid. The surface modification of the nanoparticles with folic acid was performed using an electrostatic interaction between the glutamate moiety of folic acid and CoAl LDH. The modification with FA was found to be advantageous for the controlled dissolution of LDH nanoparticles in a pH-responsive manner. Additionally, cell culture tests suggest that the materials exhibit targeting properties towards cancer cells for the enhancement of cellular uptake. The unique nanometric CoAl-LDH-based material is a good candidate to fill the gap between delaminated sheets with a single layer thickness and large well-crystallized LDHs and is promising as a Co-based nanomaterial for CDT application.

Graphical abstract: Synthesis of 20-nm-sized CoAl-LDH nanoparticles modified with folic acid for enhanced cancer cell targeting

Supplementary files

Article information

Article type
Paper
Submitted
27 Nov 2023
Accepted
01 Feb 2024
First published
05 Feb 2024
This article is Open Access
Creative Commons BY license

Mater. Adv., 2024,5, 2926-2933

Synthesis of 20-nm-sized CoAl-LDH nanoparticles modified with folic acid for enhanced cancer cell targeting

Yasuaki. Tokudome, A. Obata, N. Kitagawa, K. Nagatsuka, E. Gorai, Y. Maehashi, Y. Kishida, H. Murata, A. Nakahira and T. Kasuga, Mater. Adv., 2024, 5, 2926 DOI: 10.1039/D3MA01053H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements