Issue 7, 2024

Europium-doped hybrid nano-complexes: a potential strategy for metastasis prevention in osteosarcoma

Abstract

Metastasis is a major issue in cancer therapy, resulting in poor prognosis and death. However, there is currently no widely established prophylactic strategy for early metastasis in the clinical setting. Although water-soluble EuCl3ยท6H2O has the potential to exhibit a metastasis-inhibiting effect similar to migrastatics and matrix metalloproteinase inhibitors (MMPIs), intravenous administration of europium (Eu)-containing compound solution may not efficiently accumulate Eu ions in tumors and could be rapidly cleared from the body. In this study, we developed Eu ion-doped superparamagnetic iron oxides incorporated into bovine serum albumin hybrid nano-complexes (Eu:SPIO@BSA nano-complexes) to enhance tumor accumulation and prevent metastatic osteosarcoma via intravenous administration. In vitro studies showed that Eu:SPIO@BSA nano-complexes had a migration-inhibiting effect and affected pseudopodia formation in K7M2 cells. In vivo studies showed that distant lung metastasis was inhibited by the magnetism-enhanced targeted delivery of Eu:SPIO@BSA nano-complexes. Taken together, our results provide evidences that the Eu:SPIO@BSA nano-complex, with precise delivery, higher hemocompatibility and low liver toxicity, is a potential candidate for improving the therapeutic efficacy of metastasis prevention in osteosarcoma.

Graphical abstract: Europium-doped hybrid nano-complexes: a potential strategy for metastasis prevention in osteosarcoma

Supplementary files

Article information

Article type
Paper
Submitted
31 Oct 2023
Accepted
15 Feb 2024
First published
23 Feb 2024
This article is Open Access
Creative Commons BY-NC license

Mater. Adv., 2024,5, 2934-2945

Europium-doped hybrid nano-complexes: a potential strategy for metastasis prevention in osteosarcoma

Y. Wang, F. Tung, Z. Sung, M. Chen, M. Chen and T. Liu, Mater. Adv., 2024, 5, 2934 DOI: 10.1039/D3MA00939D

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