Photoredox catalytic aminomethylation of sulfonylthiazoles

Abstract

A photoredox catalytic aliphatic C(sp³)–H thiazolation of tertiary amines was developed, affording the biologically valuable alkylated thiazoles via the aminomethylation of sulfonylthiazoles. The reaction is metal and oxidant free, with a broad substrate scope that tolerates both aliphatic and aromatic amines. The successful applications in the gram-scale reaction and late-stage functionalization of drug-like molecules in mild conditions under room temperature have qualified the protocol to be practical and cost-effective.