Issue 11, 2024

Functionalized orthopaedic implant as pH electrochemical sensing tool for smart diagnosis of hardware infection

Abstract

In the orthopaedic surgery field, the use of medical implants to treat a patient's bone fracture is nowadays a common practice, nevertheless, it is associated with possible cases of infection. The consequent hardware infection can lead to implant failure and systemic infections, with prolonged hospitalization, time-consuming rehabilitation treatments, and extended antibiotic therapy. Hardware infections are strictly related to bacterial adhesion to the implant, leading to infection occurrence and consequent pH decreasing from physiological level to acid pH. Here, we demonstrate the new strategy to use an orthopaedic implant functionalized with iridium oxide film as the working electrode for the potentiometric monitoring of pH in hardware infection diagnosis. A functional investigation was focused on selecting the implant material, namely titanium, titanium alloy, and stainless steel, and the component, namely screws and implants. After selecting the titanium-based implant as the working electrode and a silver wire as the reference electrode in the final configuration of the smart sensing orthopaedic implant, a calibration curve was performed in standard solutions. An equation equal to y = (0.76 ± 0.02) − (0.068 ± 0.002) x, R2 = 0.996, was obtained in the pH range of 4–8. Subsequently, hysteresis, interference, matrix effect, recovery study, and storage stability were investigated to test the overall performance of the sensing device, demonstrating the tremendous potential of electrochemical sensors to deliver the next generation of smart orthopaedic implants.

Graphical abstract: Functionalized orthopaedic implant as pH electrochemical sensing tool for smart diagnosis of hardware infection

Supplementary files

Article information

Article type
Paper
Submitted
16 Feb 2024
Accepted
27 Apr 2024
First published
29 Apr 2024

Analyst, 2024,149, 3085-3096

Functionalized orthopaedic implant as pH electrochemical sensing tool for smart diagnosis of hardware infection

L. Fiore, V. Mazzaracchio, C. Gosti, L. Duranti, R. Vitiello, G. Maccauro and F. Arduini, Analyst, 2024, 149, 3085 DOI: 10.1039/D4AN00253A

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