Visible-light induced three-component reaction for α-aminobutyronitrile synthesis by C–C bond formation using quantum dots as photocatalysts

Abstract

We describe a three-component reaction of malononitrile, benzaldehyde and N,N-dimethylaniline using aluminium doped CdSeS/CdZnSeS(Al)/ZnS quantum dots (QDs) as visible light catalysts to synthesize α-aminobutyrilitriles at room temperature and under mild conditions. The reactions exhibit high functional group tolerance, and the well dispersed quantum dot catalysts are highly efficient with a turnover number (TON) greater than 1.1 × 10³ and can be recycled at least three times without significant loss of catalytic activity.