Issue 35, 2023
From the journal:

Dalton Transactions

Harnessing the dual antimicrobial mode of action with a lipophilic Mn(ii) complex using the principle of the Irving–Williams Series to completely eradicate Staphylococcus aurous†

Khalil Mudarmah,ac   Bijaya Bagale,a   Guanyu Chen,a   Jeanette A. Krause,b   Jeffrey D. Mighion*a  and  Songping D. Huang ORCID logo *a  

* Corresponding authors

a Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44240, USA
E-mail: shuang1@kent.edu

b Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221-0172, USA

c Department of Chemistry, Jazan University, Jazan, Saudi Arabia

Abstract

The judicious selection of 5,7-dibromo-2-methy-8-quinolinol (BQ) as a Mn(II) ionophore results in the synthesis of Mn(BQ)2(DMSO)2·DMSO (1), a potent metalloantibiotic with a dual antimicrobial mode of action against four different strains of Staphylococcus aurous (SA) bacteria (MIC = 0.625 μg mL−1). Additionally, 1 can overcome ciprofloxacin-resistance in methicillin-resistant SA bacteria.

Graphical abstract: Harnessing the dual antimicrobial mode of action with a lipophilic Mn(ii) complex using the principle of the Irving–Williams Series to completely eradicate Staphylococcus aurous

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Article information

DOI
https://doi.org/10.1039/D3DT01904G
Article type
Communication
Submitted
19 Jun 2023
Accepted
15 Aug 2023
First published
16 Aug 2023

Dalton Trans., 2023,52, 12203-12207

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Harnessing the dual antimicrobial mode of action with a lipophilic Mn(II) complex using the principle of the Irving–Williams Series to completely eradicate Staphylococcus aurous

K. Mudarmah, B. Bagale, G. Chen, J. A. Krause, J. D. Mighion and S. D. Huang, Dalton Trans., 2023, 52, 12203 DOI: 10.1039/D3DT01904G

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