In vivo monitoring of glutathione in a live rat brain based on the ratiometric signal output of 2D Cu-TCPP(Fe) nanosheets

Fan Zhao; Xuan Tang; Dongqing Guo

doi:10.1039/D3CC03626J

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In vivo monitoring of glutathione in a live rat brain based on the ratiometric signal output of 2D Cu-TCPP(Fe) nanosheets†

Fan Zhao,

*^a Xuan Tang^a and Dongqing Guo^a

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* Corresponding authors

^a Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Binshui West Road 393, Tianjin 300387, P. R. China
E-mail: fzhao@tjnu.edu.cn

Abstract

Herein, a novel ratiometric electrochemical platform was developed for in vivo analysis of GSH based on the dual signal output of 2D Cu-TCPP(Fe) nanosheets. Our method with high selectivity and high accuracy enabled GSH monitoring in a live rat brain, and accurate GSH concentrations were firstly reported in different brain regions upon global cerebral ischemia.

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Article information

DOI: https://doi.org/10.1039/D3CC03626J
Article type: Communication
Submitted: 27 Jul 2023
Accepted: 15 Aug 2023
First published: 17 Aug 2023

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Chem. Commun., 2023,59, 10984-10987

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In vivo monitoring of glutathione in a live rat brain based on the ratiometric signal output of 2D Cu-TCPP(Fe) nanosheets

F. Zhao, X. Tang and D. Guo, Chem. Commun., 2023, 59, 10984 DOI: 10.1039/D3CC03626J

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Chemical Communications

In vivo monitoring of glutathione in a live rat brain based on the ratiometric signal output of 2D Cu-TCPP(Fe) nanosheets†

Abstract

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In vivo monitoring of glutathione in a live rat brain based on the ratiometric signal output of 2D Cu-TCPP(Fe) nanosheets

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