Issue 49, 2023
From the journal:

Chemical Communications

Engineering ketoreductases for the enantioselective synthesis of chiral alcohols†

Li Qiao,‡a   Zhiyuan Luo,‡a   Haomin Chen,a   Pengfei Zhang, ORCID logo a   Anming Wang ORCID logo *a  and  Roger A. Sheldon ORCID logo *bc  

* Corresponding authors

a College of Materials, Chemistry and Chemical Engineering; Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education; Hangzhou Normal University, Zhejiang Province, Hangzhou, Zhejiang, P. R. China
E-mail: waming@hznu.edu.cn

b Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, PO Wits. 2050, Johannesburg, South Africa
E-mail: roger.sheldon@wits.ac.za

c Department of Biotechnology, Section BOC, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, The Netherlands

Abstract

The use of engineered ketoreductases (KREDS), both as whole microbial cells and isolated enzymes, in the highly enantiospecific reduction of prochiral ketones is reviewed. The homochiral alcohol products are key intermediates in, for example, pharmaceuticals synthesis. The application of sophisticated protein engineering and enzyme immobilisation techniques to increase industrial viability are discussed.

Graphical abstract: Engineering ketoreductases for the enantioselective synthesis of chiral alcohols

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Article information

DOI
https://doi.org/10.1039/D3CC01474F
Article type
Feature Article
Submitted
26 Mar 2023
Accepted
04 May 2023
First published
05 May 2023
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2023,59, 7518-7533

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Engineering ketoreductases for the enantioselective synthesis of chiral alcohols

L. Qiao, Z. Luo, H. Chen, P. Zhang, A. Wang and R. A. Sheldon, Chem. Commun., 2023, 59, 7518 DOI: 10.1039/D3CC01474F

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