Water-soluble terphen[3]arene macrocycle: a versatile reversal agent of neuromuscular blockers

Yibo Zhao; Longming Chen; Junyi Chen; Jian Li; Qingbin Meng; Andrew C.-H. Sue; Chunju Li

doi:10.1039/D3CC01405C

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Water-soluble terphen[3]arene macrocycle: a versatile reversal agent of neuromuscular blockers†

Yibo Zhao,^a Longming Chen,^b Junyi Chen,^bc Jian Li,

^d Qingbin Meng,

*^b Andrew C.-H. Sue

*^a and Chunju Li

*^c

Author affiliations

* Corresponding authors

^a School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300387, P. R. China
E-mail: andrewsue@xmu.edu.cn

^b State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, P. R. China
E-mail: nankaimqb@sina.com

^c Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 300387, P. R. China
E-mail: cjli@shu.edu.cn

^d School of Chemistry and Chemical Engineering, Henan Normal University, P. R. China

Abstract

Herein we report the design and synthesis of a terphen[n]arene derivative functionalised with sulfate acid ester groups. This water-soluble terphen[3]arene host effectively encapsulates a multitude of neuromuscular blocking agents (NMBAs) with high affinity, showing great potential as a NMBAs reversal agent in pharmaceutical research.

This article is part of the themed collection: 2023 Pioneering Investigators

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Article information

DOI: https://doi.org/10.1039/D3CC01405C
Article type: Communication
Submitted: 22 Mar 2023
Accepted: 14 Apr 2023
First published: 21 Apr 2023

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Chem. Commun., 2023,59, 5858-5861

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Water-soluble terphen[3]arene macrocycle: a versatile reversal agent of neuromuscular blockers

Y. Zhao, L. Chen, J. Chen, J. Li, Q. Meng, A. C.-H. Sue and C. Li, Chem. Commun., 2023, 59, 5858 DOI: 10.1039/D3CC01405C

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Chemical Communications

Water-soluble terphen[3]arene macrocycle: a versatile reversal agent of neuromuscular blockers†

Abstract

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Water-soluble terphen[3]arene macrocycle: a versatile reversal agent of neuromuscular blockers

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