Issue 26, 2023

A rigid-axle-based molecular rotaxane channel facilitates K+/Cl co-transport across a lipid membrane

Abstract

Inspired by the design criteria of heteroditopic receptors for ion-pair binding, we herein describe a new strategy to construct a rotaxane transporter (RR[2]) for K+/Cl co-transport. The use of a rigid axle improves the transport activity with an EC50 value of 0.58 μM, presenting a significant step toward developing rotaxane artificial channels.

Graphical abstract: A rigid-axle-based molecular rotaxane channel facilitates K+/Cl− co-transport across a lipid membrane

Supplementary files

Article information

Article type
Communication
Submitted
21 Feb 2023
Accepted
03 Mar 2023
First published
06 Mar 2023

Chem. Commun., 2023,59, 3866-3869

A rigid-axle-based molecular rotaxane channel facilitates K+/Cl co-transport across a lipid membrane

S. Pang, X. Sun, Z. Yan, C. Wang, K. Ye, S. Ma, L. Zhu and C. Bao, Chem. Commun., 2023, 59, 3866 DOI: 10.1039/D3CC00811H

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