Issue 38, 2023
From the journal:

Chemical Communications

Attenuation of α-synuclein aggregation by catalytic photo-oxygenation†

Atsushi Iwai,a   Reito Nakamura,b   Ikumi Tomizawa,b   Harunobu Mitsunuma, ORCID logo a   Yukiko Hori,b   Taisuke Tomita, ORCID logo b   Youhei Sohma ORCID logo *c  and  Motomu Kanai ORCID logo *a  

* Corresponding authors

a Laboratory of Synthetic Organic Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
E-mail: kanai@mol.f.u-tokyo.ac.jp

b Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

c School of Pharmaceutical Sciences, Wakayama Medical University, 25-1 Shichiban-cho, Wakayama 640-8156, Japan
E-mail: ysohma@wakayama-med.ac.jp

Abstract

We developed catalyst 11 to promote selective photo-oxygenation of α-synuclein amyloid and attenuate its aggregation. Catalyst 11 effectively oxygenated both small and large aggregates. The oxygenated α-synuclein exhibited lower seeding activity than intact α-synuclein. This study corroborates the feasibility of catalytic photo-oxygenation as an anti-synucleinopathy strategy.

Graphical abstract: Attenuation of α-synuclein aggregation by catalytic photo-oxygenation

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Article information

DOI
https://doi.org/10.1039/D3CC00665D
Article type
Communication
Submitted
13 Feb 2023
Accepted
15 Apr 2023
First published
18 Apr 2023
This article is Open Access
Creative Commons BY license

Chem. Commun., 2023,59, 5745-5748

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Attenuation of α-synuclein aggregation by catalytic photo-oxygenation

A. Iwai, R. Nakamura, I. Tomizawa, H. Mitsunuma, Y. Hori, T. Tomita, Y. Sohma and M. Kanai, Chem. Commun., 2023, 59, 5745 DOI: 10.1039/D3CC00665D

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