Selectively recognizing heptad-interfaced G-quadruplexes by a molecular rotor with an ESIPT emission

Mujing Yang; Rong Lai; Shuzhen Peng; Yun Chang; Xingli Zeng; Dandan Wang; Xiaoshun Zhou; Yong Shao

doi:10.1039/D2CC06156B

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Selectively recognizing heptad-interfaced G-quadruplexes by a molecular rotor with an ESIPT emission†

Mujing Yang,^a Rong Lai,^a Shuzhen Peng,^a Yun Chang,^a Xingli Zeng,^a Dandan Wang,*^a Xiaoshun Zhou^a and Yong Shao

*^a

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* Corresponding authors

^a Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua 321004, Zhejiang, China
E-mail: yshao@zjnu.cn, ddwang@zjnu.edu.cn

Abstract

Heptad-interfaced G-quadruplexes (G4s), formed with GGA repeats located in the nuclear proto-oncogene c-myb promoter, can be selectively targeted by a prenylated flavonol of sophoflavescenol (Sop) with restriction of molecular rotation to trigger strong excited state intramolecular proton transfer (ESIPT) emission.

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Article information

DOI: https://doi.org/10.1039/D2CC06156B
Article type: Communication
Submitted: 14 Nov 2022
Accepted: 23 Dec 2022
First published: 23 Dec 2022

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Chem. Commun., 2023,59, 1189-1192

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Selectively recognizing heptad-interfaced G-quadruplexes by a molecular rotor with an ESIPT emission

M. Yang, R. Lai, S. Peng, Y. Chang, X. Zeng, D. Wang, X. Zhou and Y. Shao, Chem. Commun., 2023, 59, 1189 DOI: 10.1039/D2CC06156B

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Chemical Communications

Selectively recognizing heptad-interfaced G-quadruplexes by a molecular rotor with an ESIPT emission†

Abstract

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Selectively recognizing heptad-interfaced G-quadruplexes by a molecular rotor with an ESIPT emission

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