Issue 7, 2023

Bioengineering of BRAF and COX2 inhibitor nanogels to boost the immunotherapy of melanoma via pyroptosis

Abstract

Glutathione-responsive nanogels (CDNPs) crosslinked via crosslinker DBHD with the BRAF inhibitor dabrafenib and the COX2 inhibitor celecoxib were fabricated. The CDNPs can effectively induce tumor cell pyroptosis to activate robust antitumor immunity. Additionally, CDNPs combined with αPD-1 antibody greatly inhibited tumor growth in a melanoma mouse model with a prolonged survival time.

Graphical abstract: Bioengineering of BRAF and COX2 inhibitor nanogels to boost the immunotherapy of melanoma via pyroptosis

Supplementary files

Article information

Article type
Communication
Submitted
12 Oct 2022
Accepted
12 Dec 2022
First published
04 Jan 2023

Chem. Commun., 2023,59, 932-935

Bioengineering of BRAF and COX2 inhibitor nanogels to boost the immunotherapy of melanoma via pyroptosis

M. Zhang, M. Liang, S. Yang, X. Ma, S. Wan, Q. Yang, S. Wang, Z. Xu and Z. Sun, Chem. Commun., 2023, 59, 932 DOI: 10.1039/D2CC05498A

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