Issue 7, 2023
From the journal:

Chemical Communications

Hoechst-tagged radioiodinated BODIPY derivative for Auger-electron cancer therapy†

Ryotaro Onoue,a   Hiroyuki Watanabe ORCID logo *a  and  Masahiro Ono ORCID logo *a  

* Corresponding authors

a Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan
E-mail: hwatanabe@pharm.kyoto-u.ac.jp, ono@pharm.kyoto-u.ac.jp
Fax: +81-75-753-4568
Tel: +81-75-753-4566

Abstract

Targeted radionuclide therapy using Auger electrons is a promising strategy in cancer treatment. A DNA-binding Hoechst-tagged radioiodinated BODIPY derivative ([125I]BH) has been prepared as an Auger therapeutic agent. [125I]BH showed high accumulation in the nucleus of HeLa cells and cytotoxicity caused by DNA double-strand breaks.

Graphical abstract: Hoechst-tagged radioiodinated BODIPY derivative for Auger-electron cancer therapy

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D2CC05405A
Article type
Communication
Submitted
03 Oct 2022
Accepted
19 Dec 2022
First published
04 Jan 2023

Chem. Commun., 2023,59, 928-931

Permissions

Request permissions

Hoechst-tagged radioiodinated BODIPY derivative for Auger-electron cancer therapy

R. Onoue, H. Watanabe and M. Ono, Chem. Commun., 2023, 59, 928 DOI: 10.1039/D2CC05405A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements