Electrochemically enhanced deoxygenative cross-coupling of aryl ketones with heteroarenes through in situ generated benzyl carbocations

Abstract

Triflic acids/silanes as cooperative reductants enable the convenient transformation of C[double bond, length as m-dash]O bonds through a multistep reaction pathway in one pot. Electrolysis of the acidic reaction mixture significantly improved carbonyl reduction and thus facilitated the generation of benzyl carbocations, which show high reactivity towards electron-rich heteroarenes for C–C bond formation.

Graphical abstract: Electrochemically enhanced deoxygenative cross-coupling of aryl ketones with heteroarenes through in situ generated benzyl carbocations

Supplementary files

Article information

Article type
Communication
Submitted
11 Nov 2022
Accepted
21 Nov 2022
First published
22 Nov 2022

Org. Biomol. Chem., 2022, Advance Article

Electrochemically enhanced deoxygenative cross-coupling of aryl ketones with heteroarenes through in situ generated benzyl carbocations

Y. Zhang, J. Hou, H. Yang, S. Wang and K. Yuan, Org. Biomol. Chem., 2022, Advance Article , DOI: 10.1039/D2OB02065C

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