Issue 43, 2022

Rh(ii)-catalyzed synthesis of 5H-isochromeno[3,4-b]indolizines from 4-diazoisochroman-3-imines and pyridines

Abstract

A Rh(II)-catalyzed (3 + 2) annulation of pyridines with 4-diazoisochroman-3-imines leading to 5H-isochromeno[3,4-b]indolizines is presented. This methodology provides straightforward access to a wide variety of substituted 5H-isochromeno[3,4-b]indolizines with moderate to good yields (up to 84%) and complete regioselectivity.

Graphical abstract: Rh(ii)-catalyzed synthesis of 5H-isochromeno[3,4-b]indolizines from 4-diazoisochroman-3-imines and pyridines

Supplementary files

Article information

Article type
Paper
Submitted
01 Aug 2022
Accepted
11 Oct 2022
First published
14 Oct 2022

Org. Biomol. Chem., 2022,20, 8484-8488

Rh(II)-catalyzed synthesis of 5H-isochromeno[3,4-b]indolizines from 4-diazoisochroman-3-imines and pyridines

Y. Wang, J. Xie, P. Lu and Y. Wang, Org. Biomol. Chem., 2022, 20, 8484 DOI: 10.1039/D2OB01400A

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