Issue 38, 2022

Incorporation of a cyclobutyl substituent in molecules by transition metal-catalyzed cross-coupling reactions

Abstract

In this review, the incorporation of a cyclobutyl substituent in molecules, by transition metal-catalyzed cross-coupling, is described by only considering the formation of C–C bonds. Three main strategies are used to introduce a cyclobutyl substituent in molecules by involving either electrophilic or nucleophilic cyclobutane derivatives.

Graphical abstract: Incorporation of a cyclobutyl substituent in molecules by transition metal-catalyzed cross-coupling reactions

Article information

Article type
Review Article
Submitted
03 Jun 2022
Accepted
09 Sep 2022
First published
23 Sep 2022

Org. Biomol. Chem., 2022,20, 7529-7553

Incorporation of a cyclobutyl substituent in molecules by transition metal-catalyzed cross-coupling reactions

J. Cossy, P. Polàk and P. C. Ruer, Org. Biomol. Chem., 2022, 20, 7529 DOI: 10.1039/D2OB01045C

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