Issue 20, 2022

Flavin catalyzed desulfurization of peptides and proteins in aqueous media

Abstract

A biomimetic method has been established for the chemo-selective desulfurization of cysteinyl peptides and proteins in aqueous media. The derivatives of biocatalytic cofactors, flavins, were found to be efficient photosensitizers in a thiyl-radical-mediated desulfurization of Cys. The reaction was conducted in an ultrafast manner with both polypeptides and proteins.

Graphical abstract: Flavin catalyzed desulfurization of peptides and proteins in aqueous media

Supplementary files

Article information

Article type
Communication
Submitted
05 Apr 2022
Accepted
03 May 2022
First published
03 May 2022

Org. Biomol. Chem., 2022,20, 4105-4109

Flavin catalyzed desulfurization of peptides and proteins in aqueous media

C. Wan, D. Yang, X. Qin, Z. Xue, X. Guo, Z. Hou, C. Jiang, F. Yin, R. Wang and Z. Li, Org. Biomol. Chem., 2022, 20, 4105 DOI: 10.1039/D2OB00641C

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