Issue 20, 2022

Ni-catalysed deamidative fluorination of amides with electrophilic fluorinating reagents

Abstract

We describe here a Ni-catalysed deamidative fluorination of diverse amides with electrophilic fluorinating reagents. Different types of amides including aromatic amides and olefinic amides were well compatible, affording the corresponding acyl fluorides in good to excellent yields.

Graphical abstract: Ni-catalysed deamidative fluorination of amides with electrophilic fluorinating reagents

Supplementary files

Article information

Article type
Communication
Submitted
17 Mar 2022
Accepted
22 Apr 2022
First published
23 Apr 2022

Org. Biomol. Chem., 2022,20, 4091-4095

Ni-catalysed deamidative fluorination of amides with electrophilic fluorinating reagents

F. Wu, Y. Mao, J. Pu, H. Li, P. Ye, Z. Xu, S. Lou and D. Xu, Org. Biomol. Chem., 2022, 20, 4091 DOI: 10.1039/D2OB00519K

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