Issue 23, 2022

Ruthenium-catalyzed (spiro)annulation of N-aryl-2,3-dihydrophthalazine-1,4-diones with quinones to access pentacyclic spiro-indazolones and fused-cinnolines

Abstract

Ru(II)-catalyzed strategies were developed for the [4 + 1] and [4 + 2] oxidative coupling between N-aryl-2,3-dihydrophthalazine-1,4-diones and 1,4-benzoquinones, achieving spiro-indazolones and fused-cinnolines, respectively. Mild, aerobic and external oxidant-free conditions, as well as the use of a ruthenium catalyst for such (spiro)annulative strategies with quinones over reported Rh/Ir-catalyts, underline the rewards of the disclosed protocols.

Graphical abstract: Ruthenium-catalyzed (spiro)annulation of N-aryl-2,3-dihydrophthalazine-1,4-diones with quinones to access pentacyclic spiro-indazolones and fused-cinnolines

Supplementary files

Article information

Article type
Paper
Submitted
14 Mar 2022
Accepted
09 May 2022
First published
11 May 2022

Org. Biomol. Chem., 2022,20, 4753-4764

Ruthenium-catalyzed (spiro)annulation of N-aryl-2,3-dihydrophthalazine-1,4-diones with quinones to access pentacyclic spiro-indazolones and fused-cinnolines

S. Naharwal, P. Karishma, C. K. Mahesha, K. Bajaj, S. K. Mandal and R. Sakhuja, Org. Biomol. Chem., 2022, 20, 4753 DOI: 10.1039/D2OB00493C

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