Photoredox-catalyzed fluorodifluoroacetylation of alkenes with FSO2CF2CO2Me and Et3N·3HF

Song Zou; Xuewei Luo; Chao Chen; Chanjuan Xi

doi:10.1039/D2OB00488G

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Photoredox-catalyzed fluorodifluoroacetylation of alkenes with FSO₂CF₂CO₂Me and Et₃N·3HF†

Song Zou,^a Xuewei Luo,^a Chao Chen

*^a and Chanjuan Xi

*^ab

Author affiliations

* Corresponding authors

^a MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, China
E-mail: cjxi@tsinghua.edu.cn, chenchao01@mails.tsinghua.edu.cn

^b State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, China

Abstract

Photoredox-catalyzed three-component fluorodifluoroacetylation of aromatic alkenes is reported, which features a wide substrate scope and functional group tolerance. An advantage of the reaction is the use of a nucleophilic fluoride source and a general difluoroacetylation reagent for the fluorodifluoroacetylation of alkenes.

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Article information

DOI: https://doi.org/10.1039/D2OB00488G
Article type: Communication
Submitted: 12 Mar 2022
Accepted: 13 Apr 2022
First published: 14 Apr 2022

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Org. Biomol. Chem., 2022,20, 3726-3730

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Photoredox-catalyzed fluorodifluoroacetylation of alkenes with FSO₂CF₂CO₂Me and Et₃N·3HF

S. Zou, X. Luo, C. Chen and C. Xi, Org. Biomol. Chem., 2022, 20, 3726 DOI: 10.1039/D2OB00488G

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Organic & Biomolecular Chemistry