Issue 18, 2022
From the journal:

Organic & Biomolecular Chemistry

A simple iodine–DMSO-promoted multicomponent reaction for the synthesis of 2,4-disubstituted dihydrotriazole-3-ones†

Hui Liao,a   Zesheng Huanga  and  Qiuhua Zhu ORCID logo *a  

* Corresponding authors

a Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou 510515, China
E-mail: zhuqh@smu.edu.cn
Fax: +86 20 61647627

Abstract

A series of 2,4-disubstituted 1,2,4-triazole-3-ones 4 were prepared via an iodine–DMSO-promoted three-component reaction of formaldehyde, amines and hydrazines in moderate yields.

Graphical abstract: A simple iodine–DMSO-promoted multicomponent reaction for the synthesis of 2,4-disubstituted dihydrotriazole-3-ones

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Article information

DOI
https://doi.org/10.1039/D2OB00352J
Article type
Communication
Submitted
20 Feb 2022
Accepted
08 Apr 2022
First published
08 Apr 2022

Org. Biomol. Chem., 2022,20, 3721-3725

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A simple iodine–DMSO-promoted multicomponent reaction for the synthesis of 2,4-disubstituted dihydrotriazole-3-ones

H. Liao, Z. Huang and Q. Zhu, Org. Biomol. Chem., 2022, 20, 3721 DOI: 10.1039/D2OB00352J

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