Arylopeptoid oligomers functionalised by combinatorial or sequential on-resin click chemistry using a copper(i)–N-heterocyclic carbene catalyst

Abstract

An efficient on-resin click chemistry protocol using a stable copper(I)–N-heterocyclic carbene catalyst is developed for post-functionalization of N-alkylated aminomethylbenzamide oligomers (arylopeptoids). The accessibility to a panel of polyfunctionalized N-substituted aromatic oligoamides by solid-phase synthesis is demonstrated using combinatorial and sequential approaches.